INTROL MTHFR Genotype Control is intended for in vitro use as a control product to monitor the analytical performance of extraction, amplification and detection of test systems used in qualitative measurment of the methylenetetrahydrofolate reductase (MTHFR) gene for mutations C677T and A1298C.  MTHFR mutations C677T and A1298C are associated with thrombosis, cancers, leukemias, neural tube defects, high homocystine levels, cardiovascular disease, schizophrenia, Alzheimer’s and toxicity of anti-folate drugs like methotrexate.

Routine use of INTROL MTHFR Genotype Control with each MTHFR C677T and A1298C test run will assist the laboratory in the detection of immediate errors, and shifts or trends caused by changes in test system components. Analysis of INTROL MTHFR Genotype Control also provides the laboratory with valuable experience by demonstrating test results of rare genotypes.

INTROL MTHFR Genotype Control is to be extracted before analysis just as patient whole blood samples are, which allows the control to fit efficiently into normal laboratory work flow. The unique extractability characteristic provides monitoring of the extraction step as required by CLIA regulations and best laboratory practice.

Each bottle of MTHFR Genotype Control contains two synthetic alleles of MTHFR DNA suspended in a non-infectious, blood-like matrix. Each allele contains a segment of the MTHFR gene. One allele carries mutations C677T and A1298C and the other allele carries only wild type DNA. The two alleles have been carefully mixed to produce three bottles containing three different genotypes: homozygous wild type (WT/WT), heterozygous (C677T/ WT and A1298C/ WT), and homozygous mutant (C677T/ C677T and A1298C/ A1298C). Both alleles have been quality scored sequenced in entirety.

Please contact MMQCI at 207-885-1072 or e-mail us with any questions you may have.

INTROL™ MTHFR Genotype Control is provided for Research Use Only.

Material Safety Data Sheet