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MTHFR
INTROL™ MTHFR Genotype
Control
Catalog #
G105 3 bottles* x 2 mL
*MTHFR Wild type, MTHFR
Heterozygous, MTHFR Mutant
CF
Panel 1
Thrombotic
Risk
MTHFR mutations C677T
and A1298C are associated with thrombosis,
cancers, leukemias, neural tube defects, high homocystine
levels, cardiovascular disease, schizophrenia, Alzheimer’s and
toxicity of anti-folate drugs like methotrexate. Our MTHFR
Genotype Control is
an external quality control used to monitor the analytical
performance of the extraction, amplification and detection of
test systems used in the qualitative measurement of the
methylenetetrahydrofolate reductase (MTHFR) gene for mutations
C677T and A1298C.
Each bottle of MTHFR Genotype Control contains
two synthetic alleles of MTHFR DNA suspended in a
non-infectious, blood-like matrix. Each allele contains a
segment of the MTHFR gene. One allele carries mutations C677T
and A1298C and the other allele carries only wild
type DNA. Both alleles have been quality scored sequenced in
entirety.
Analysis of MTHFR Genotype Control provides the
laboratory with valuable experience by demonstrating test
results of rare genotypes.
The two alleles have been carefully mixed to produce three
bottles containing three different genotypes: homozygous wild
type (WT/WT), heterozygous (C677T/ WT and A1298C/
WT), and homozygous mutant (C677T/ C677T and A1298C/
A1298C).
INTROL™ is provided for
Research Use Only.
MSDS
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